Very unreliable memory speaking--but I think in either the first or second ep, he does imply soemthing like that in regards to his leg--that the doctors refused to listen/didn't know why his leg was in chronic pain and it ended in a leg-stroke (I guess a blockage in his leg?), hence the fact he doesn't have full use and pops vicadin, and possibly why he's so hot for trial and error in diagnostic medicine.

I think you are right...wow, can't believe I forgot about that. Last night they also made it TEXT that there was an extreme personality change when he had his infarction (is that how it is spelled?), verified by House who knew him before the medical problem surfaced.