You know, I've pondered that myself, because although I've never had a serious situation in which it manifested, I've had issues my entire adult life with doctors not taking me seriously (which I'd gotten used to as a child and adolescent - my mother was a nurse, so doctors asssumed both she and I knew what we were talking about).

If I had a doctor like House in real life, I'd have walked out of the clinic in under five minutes. And while there've been one or two episodes (particularly the one with the sick teens, when they just flat-out refused to listen to the mother) where I've winced. Mostly, I can just disconnect it from how I'd react in real life, but I get how someone couldn't. I don't think, for example, that I could do that if House were a teacher treating students like that.